Survival outcomes of expansile versus infiltrative subtype in primary mucinous ovarian carcinomas: A retrospective study in Thailand.

Authors

Thiti Atjimakul, Kulisara Nanthamongkolkul, Aroonsawad Charoenvikkai, Kanet Kanjanapradit

Published in

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics. Aug 24, 2026. Epub Aug 24, 2026.

Abstract

To compare the prognostic outcomes of the expansile and infiltrative subtypes of primary mucinous ovarian carcinoma (PMOC).
This retrospective cohort study involved patients with PMOC who underwent surgery between 2018 and 2023. All specimens were re-evaluated by an expert pathologist according to the 2020 WHO classification and categorized as expansile or infiltrative subtypes. Overall survival (OS) and progression-free survival (PFS) were evaluated using Kaplan-Meier analysis. Univariate and multivariate Cox regression analyses were performed to identify independent factors associated with OS and PFS.
Among 65 cases of PMOC, 38 (58.5%) were classified as expansile and 27 (41.5%) as infiltrative. The median follow-up duration was 33 (range, 1-86 months). Five-year OS and PFS rates did not differ significantly between the two subtypes (79.2% vs. 73.5%, P = 0.37; 82.5% vs. 79.2%, P = 0.40; respectively). In multivariate analysis, the invasion pattern was not an independent prognostic factor; instead, advanced stage (hazard ratio [HR], 5.10; 95% confidence interval [CI]: 1.06-24.55; P = 0.04) and residual tumor ≥1 cm (HR 11.26, 95% CI: 1.11-114.21; P = 0.04) were independently associated with worse PFS. For overall survival, only residual tumor ≥1 cm remained an independent adverse prognostic factor (HR 37.17, 95% CI: 2.71-510.07; P = 0.007).
Pathologic subtype was not independently associated with survival after adjustment for stage and residual disease; however, the limited sample size and low number of outcome events may have reduced the ability to detect clinically meaningful differences. Stage and residual disease were the dominant prognostic factors.

PMID:
42635467
Bibliographic data and abstract were imported from PubMed on 24 Aug 2026.

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