A facile synthesis toward C2-perfluoroalkylated free (NH)-indoles with excellent regioselectivity.

Authors

Zhiyong Yang, Jiaqi Yan, Qingyan Ren, Liangjie Tan, Jing Deng, Kaihua Zhang, Jing Guo

Published in

Chemical communications (Cambridge, England). Aug 25, 2026. Epub Aug 25, 2026.

Abstract

A simple, efficient and mild strategy has been developed for the synthesis of C2-perfluoroalkylated (NH)-indoles from indoles and perfluoroalkyl iodides, with DIPEA serving as the sole base. This protocol furnishes structurally diverse perfluoroalkylated indoles in good yields, features broad substrate scope and excellent functional group tolerance, and is operationally facile, thus showing great potential for synthetic applications.

PMID:
42638603
Bibliographic data and abstract were imported from PubMed on 25 Aug 2026.

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