International Consensus Criteria for the Diagnosis, Treatment Initiation, and Response Assessment for T-LGL Leukemia.

Authors

Jonathan E Brammer, Natali Pflug, Renato Zambello, Julia Almeida, Dima El-Sharkawi, Lubomir Sokol, David Feith, Zachary Braunstein, Miguel Ruiz, Till Braun, Tony Marchand, Satu Mustjoki, Carlos Bravo-Perez, Monika Brüggemann, Pierluigi Porcu, Fumihiro Ishida, Jaroslaw P Maciejewski, Marshall E Kadin, Gianpietro Semenzato, Anton W Langerak, Thierry Lamy, Thomas P Loughran, Marco Herling

Published in

Blood. Aug 21, 2026. Epub Aug 21, 2026.

Abstract

Large granular lymphocytic leukemia (LGLL) is an uncommon and likely under-diagnosed leukemia that causes severe neutropenia and anemia and can have profound effects on the quality of life for afflicted patients. Frequently associated with various auto-immune phenomena, LGLL is a paradigm for a highly interdisciplinary disease. Recent advances in our pathobiological understanding of LGLL, along with the development of novel agents, have stimulated a growing number of clinical trials and innovative approaches targeting this disease. Currently, the absence of uniform diagnostic and response criteria for LGLL results in significant heterogeneity in diagnosis and response assessment across studies. Furthermore, with the emergence of a variety of novel experimental therapeutics and an increasing number of clinical trials, it becomes critical to better define the key diagnostic, treatment and response parameters for this disease. The International LGLL Consortium was created to develop cross-disciplinary expert consensus on uniform diagnostic, treatment, and response criteria for LGLL suitable for both routine clinical use and interventional trials while facilitating cross-study comparisons. Utilizing an evidence-based framework, along with the international panel that comprises the LGLL Consortium, this report delineates the key criteria that will serve as a foundation for both the clinical management and future investigations in LGLL.

PMID:
42640859
Bibliographic data and abstract were imported from PubMed on 26 Aug 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.