Autoimmune Hepatitis in Two Patients with Behçet's Disease: A Case Report.

Authors

Majid Alikhani, Seyed Mohammad Tavangar, Mina Nikvarz, Somayeh Soroureddin

Published in

Modern rheumatology case reports. Aug 25, 2026. Epub Aug 25, 2026.

Abstract

Behçet's disease (BD) is a multisystem inflammatory disorder with variable manifestations. Although hepatic involvement is rare, abnormal liver enzymes may occasionally be observed. We describe two patients with BD who developed autoimmune hepatitis (AIH), confirmed by liver biopsy.
We report two Iranian patients-one male and one female-diagnosed with BD, who later developed persistently elevated liver enzymes. Both had elevated IgG levels, negative viral hepatitis markers, and liver biopsy findings compatible with autoimmune hepatitis (AIH). Due to limited retrospective serologic data, the diagnosis was established based on multidisciplinary clinicopathological assessment and response to immunosuppressive therapy. Sonography showed fatty liver in both cases. Treatment with azathioprine and prednisolone led to normalization of liver enzymes over a long-term follow-up.
Although uncommon, AIH can co-occur with BD and should be considered in patients with persistently elevated transaminases. Liver biopsy is crucial for definitive diagnosis. Early immunosuppressive therapy can prevent disease progression.

PMID:
42640946
Bibliographic data and abstract were imported from PubMed on 26 Aug 2026.

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