Revisiting the type II secretion system: it is more than you might think.

Authors

Nicholas P Cianciotto, Joshua Mayoral, James A Garnett

Published in

Microbiology and molecular biology reviews : MMBR. Pages e0011825. Aug 26, 2026. Epub Aug 26, 2026.

Abstract

SUMMARYOne of the first gram-negative protein secretion systems to be discovered was the type II secretion system (T2SS), in which proteins first cross the inner membrane mainly via the Sec translocon, and then are recognized and carried across the outer membrane by the multiprotein T2SS apparatus. With its erstwhile appellation as the main terminal branch of the general secretory pathway, the T2SS has sometimes been described as (only) secreting a relatively small number of degradative enzymes for the purpose of nutrient acquisition. However, as comprehensively reviewed here, the T2SS is a great deal more than this, e.g., it (i) can secrete and expose on the cell surface over 100 proteins, (ii) is a major mediator of virulence against humans, animals, and plants, secreting diverse substrates that target essentially every step in the pathogenic process, (iii) promotes biofilm formation and environmental reactions such as metal reduction, (iv) has functional interactions with other secretion systems, and (v) has a homolog in mitochondria. Moreover, current assessment of the literature reveals an underappreciated role for the T2SS in both interbacterial antagonism and bacterial competition with fungi, protozoa, and perhaps algae. We also assembled data indicating that the T2SS mediates bacterial resistance to antibiotics. Finally, the T2SS is a fascinatingly complex "machine" whose contributing parts can vary and whose ability to recognize substrates is primarily conformational, involving spatially separated elements that interact with the T2SS apparatus through transient, multivalent interactions rather than a single dedicated binding motif.

PMID:
42644602
Bibliographic data and abstract were imported from PubMed on 26 Aug 2026.

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