Reanalyzing a Randomized Controlled Trial of Invasive Aspergillosis Using a Desirability of Outcome Ranking Approach: Voriconazole Versus Amphotericin B Deoxycholate.

Authors

Julio C Zuniga-Moya, Marcela Araujo de Oliveira Santana, Luis Ostrosky-Zeichner, George R Thompson, Thomas J Walsh, Andrej Spec

Published in

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. Aug 26, 2026. Epub Aug 26, 2026.

Abstract

Efficacy of antifungal therapy in invasive aspergillosis relies primarily on mortality, overlooking critical measures of treatment response. We used the Mycoses Study Group Education & Research Consortium (MSG) Desirability of Outcome Ranking (DOOR) framework to assess efficacy of antifungal therapies by integrating mortality, treatment failure, and severe adverse events. Voriconazole achieved better overall outcomes than amphotericin B using the DOOR approach.

PMID:
42644615
Bibliographic data and abstract were imported from PubMed on 26 Aug 2026.

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