Arylsulfonium salt-mediated SO₂ incorporation to synthesize aryl sulfones.

Authors

Yan Liu, Liangke Guo, Rui Li, Kai Sun, Bing Yu

Published in

Chemical communications (Cambridge, England). Aug 26, 2026. Epub Aug 26, 2026.

Abstract

Arylsulfonyl-containing compounds play important roles in pharmaceuticals, agrochemicals, and materials science. Among the available synthetic approaches, SO₂-insertion strategies have emerged as powerful and versatile platforms for constructing sulfonyl-containing molecules from simple precursors. In radical processes, sulfur dioxide surrogates release SO₂, which is trapped by aryl radicals to generate sulfonyl radicals that can subsequently participate in diverse bond-forming reactions. Arylsulfonium salts have attracted increasing attention as aryl-radical precursors because of their facile synthesis, bench stability, and operational convenience. This review summarizes recent progress in arylsulfonium salt-enabled SO₂-insertion reactions, with particular emphasis on the mechanistic divergence of sulfonyl radicals into distinct reaction manifolds, including radical-polar crossover, metal capture, hydrogen-atom transfer/rearrangement, and radical-radical coupling.

PMID:
42644386
Bibliographic data and abstract were imported from PubMed on 26 Aug 2026.

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