Body roundness index, frailty, and prevalent self-reported stroke: An exploratory cross-sectional decomposition analysis.

Authors

Zekai Hu, Jie Zhuang, Jinyan Wang, Xieyun Jin, Lei Fang, Jun Hu

Published in

Annals of the Academy of Medicine, Singapore. Aug 20, 2026. Epub Aug 20, 2026.

Abstract

Prior NHANES studies have reported nonlinear associations of the body roundness index (BRI) with prevalent stroke and frailty. The authors updated these observations using NHANES 1999-2023 and examined the additional contribution of frailty to the BRI-prevalent self-reported stroke association.
This cross-sectional study included 36,324 adults. Stroke was defined by self-reported physician diagnosis. Survey-weighted logistic regression and restricted cubic splines were used to assess BRI associations. Expanded models were fitted with and without the frailty index (FI). A post hoc 2-piecewise model estimated a potential BRI breakpoint using 1000 bootstrap resamples. Incremental discrimination was evaluated across nested age-sex, age-sex-BRI, and age-sex-BRI-FI models. Analyses were interpreted as cross-sectional associations.
In the primary adjusted model, higher BRI was associated with prevalent self-reported stroke (odds ratio [OR]=1.08, 95% confidence interval [CI] 1.05-1.12). The spline showed increasing odds across lower-to-middle BRI values, followed by attenuation at higher values. The exploratory breakpoint was 6.34 (bootstrap 95% CI 6.14-7.65). In expanded sensitivity analyses, the BRI estimate was attenuated without FI (OR=1.01, 95% CI 0.98-1.04) and became inverse after FI was included (OR=0.91, 95% CI 0.88-0.95). FI remained strongly associated with prevalent self-reported stroke (OR=2.38 per 0.1-unit increase, 95% CI 2.23-2.54). Adding BRI to age and sex increased area under the curve (AUC) from 0.763 to 0.769, while adding FI increased AUC to 0.868.
BRI showed a nonlinear, model-dependent association with prevalent self-reported stroke, and frailty provided additional cross-sectional information. These findings support prospective evaluation of BRI and frailty as complementary markers in stroke-related assessment.

PMID:
42644538
Bibliographic data and abstract were imported from PubMed on 26 Aug 2026.

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