Authors
Rui Kong, Wei Xia, Chao Zhang, Bingjie Liu, Yidi Zheng, Zhiqi Wang
Published in
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. Volume 42. Issue 1. Pages 2720976. Dec 31, 2026. Epub Aug 26, 2026.
Abstract
Given accumulating data implicating insulin resistance (IR) in endometrial carcinogenesis, this study evaluated whether eGDR-a feasible non-invasive IR metric-is associated with self-reported endometrial cancer in a cross-sectional population-based sample.
The analytical sample consisted of 31,666 female NHANES respondents (1999-2018), including 248 EC cases versus 31,418 cancer-free comparators. Propensity score matching (1:1) controlled for baseline imbalances.
The eGDR was significantly lower in the EC group (6.84 ± 2.76) than in the control group (7.51 ± 2.66) (P = 0.004). After adjusting for confounding variables, the odds ratio (OR) for eGDR as a inversely associated with self-reported EC was 0.906 (95% CI: 0.826-0.991, P = 0.0328). A significant decreasing trend in EC risk was observed across eGDR quartiles. After covariate adjustment, eGDR remained inversely associated with EC (Model 2: OR 0.917, 95% CI 0.849-0.988, P = 0.024; Model 3: OR 0.906, 95% CI 0.826-0.991, P = 0.0328). Additionally, the restricted cubic spline revealed a significant nonlinear correlation between eGDR and the risk of EC.
In this large cross-sectional study, higher eGDR was associated with lower odds of prevalent self-reported EC. These findings suggest a link between insulin sensitivity and endometrial cancer that warrants prospective evaluation.
PMID:
42647182
Bibliographic data and abstract were imported from PubMed on 27 Aug 2026.
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