Managing testosterone deficiency in primary care: an international expert consensus.

Authors

Janine David, Carol Burté, Emmett Byrne, Paul Downie, Geoffrey Hackett, T Hugh Jones, Mohit Khera, Martin Miner, Abdulmaged M Traish, Femke Anne Maria Van Gennip, Michael Zitzmann, Abraham Morgentaler

Published in

The aging male : the official journal of the International Society for the Study of the Aging Male. Volume 29. Issue 1. Pages 2716438. Dec 31, 2026. Epub Aug 26, 2026.

Abstract

Testosterone deficiency (TD) has traditionally been managed by specialists, yet there is growing public demand for general practitioners (GPs) to become involved in the care of these men. Most TD cases initially present to GPs, and common medical conditions associated with TD are already managed by GPs, including obesity, diabetes, anaemia, and impaired mood. However, there has been scant clinical guidance or education for GPs on this topic.
To provide consensus-based expert clinical guidance on the management of TD for GPs.
International multidisciplinary consensus initiative sponsored by the Androgen Society.
An international panel of experts- including GPs, endocrinologists, urologists, andrologists, and clinical chemists- convened in Amsterdam in November 2025 to establish key points of guidance (resolutions) for GPs wishing to manage TD. Resolutions were subsequently refined in an iterative consensus process.
Unanimous consensus was achieved for all ten resolutions, covering diagnosis, treatment, monitoring, and recommendations for referral to specialists for selected populations. Key points included the requirement of symptoms and/or signs of TD combined with low values of either total or free testosterone to initiate testosterone therapy (TTh); total testosterone concentrations less than 12 nmol/L (350 ng/dl) are considered low; and monitoring for symptom response and biochemical abnormalities is essential. Large randomized clinical trial data reveals TTh is not associated with increased cardiovascular or prostate cancer risks.
These evidence-based, clinical recommendations serve as a practical guide for GPs wishing to incorporate the evaluation and management of men with TD into their practices.

PMID:
42647144
Bibliographic data and abstract were imported from PubMed on 27 Aug 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.