Epigenetics, Structural Determinants, and Race: An Integrated Conceptual Framework for Embodied Stress, Resilience, and Black Women's Cardiometabolic Health.

Authors

Latesha K Harris, Shila K Nordone, Keisha L Bentley-Edwards, Schenita D Randolph

Published in

ANS. Advances in nursing science. Volume 49. Issue 2. Pages 210-217. Epub May 08, 2026.

Abstract

By integrating epigenetic science using a multidisciplinary approach, grounded in nursing theory, this concept paper offers a transformative frontier for understanding and addressing cardiometabolic health inequities experienced by Black women. Building on the legacy and insights of the Black Women's Health Study and drawing on the Social Ecological Model, the Neuman Systems Model, and the weathering hypothesis, we present a conceptual framework that elucidates how systemic drivers of health shape cardiometabolic health outcomes through psychosocial pathways that mediate epigenetic changes. Methodological and ethical considerations, and implications for theory development, practice, and policy, are discussed.

PMID:
42647779
Bibliographic data and abstract were imported from PubMed on 27 Aug 2026.

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