Esophageal cancer-associated thoracic central venous obstruction type 2 which occurred during chemoradiotherapy.

Authors

Yoshiki Tokunaga, Kohei Hayashi, Rie Uehara, Amane Jubashi, Tomonori Araki, Takuya Honda, Hisamitsu Miyaaki

Published in

Internal medicine (Tokyo, Japan). Aug 25, 2026. Epub Aug 25, 2026.

Abstract

Thoracic central venous obstruction (TCVO) can cause facial and upper extremity edema and it is often associated with malignancies. We herein report a rare case of cervical esophageal squamous cell carcinoma complicated by TCVO type 2 during chemoradiotherapy. Approximately 1 week after starting 5-fluorouracil plus cisplatin with radiotherapy, the patient developed acute painful swelling of the left arm. Contrast-enhanced computed tomography revealed thrombosis of the left internal jugular vein with extrinsic compression of the ipsilateral subclavian vein by a cervical tumor. Symptoms improved after anticoagulation therapy while chemoradiotherapy was continued, although the improvement was likely multifactorial.

PMID:
42649070
Bibliographic data and abstract were imported from PubMed on 27 Aug 2026.

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