Changes in Intestinal Microbiota Tracked Using Next-generation Sequencing Before and after Antimicrobial Administration: An Example of Short-bowel Syndrome.

Authors

Jumpei Hasumi, Gaku Harata

Published in

Internal medicine (Tokyo, Japan). Aug 25, 2026. Epub Aug 25, 2026.

Abstract

Although patients with short bowel syndrome may receive antimicrobial therapy for complications associated with abnormal intestinal microbiota, no established criteria for target bacterial screening or antimicrobial susceptibility standards exist. As a result, antimicrobial therapy is often administered without a microbiological evaluation. However, this approach carries uncertainties and risks, as antimicrobials can alter the microbiota in undesirable ways. To address this issue, we administered antimicrobial therapy to a patient with short bowel syndrome associated with chronic metabolic acidosis and monitored the changes in the intestinal microbiota using next-generation sequencing. We report these findings as they provide new insights into short bowel syndrome.

PMID:
42649054
Bibliographic data and abstract were imported from PubMed on 27 Aug 2026.

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