Authors
Mira Jagodich, Dominik Németh, Adrienn Tóth, Erzsébet Temesvári, Péter Holló, Zsuzsanna Zsófia Szalai, Györgyi Pónyai
Published in
Contact dermatitis. Aug 26, 2026. Epub Aug 26, 2026.
Abstract
Dental treatments are increasingly common; materials continuously evolve, while long-term detailed data of hypersensitivity reactions are limited.
Investigating the prevalence, characteristics, co-sensitisation rates of metals, (meth)acrylates and other allergens related to the medical history of dental patients at a university centre in Hungary.
This retrospective study included 918 patients patch tested between 2007 and 2024 with dental screening series, stratified into pre-defined clinical subgroups.
60.3% of the tested patients were positive for at least one allergen. Metal hypersensitivity was detected in 51.4%, (meth)acrylate in 6.1%, 'other' allergens in 21.8%. Mostly multiple positive patch test reactions were observed (69%). Reactions first becoming positive only on D7 were observed in 68.4% of the tested allergens. Among patients with gingivostomatitis, oral lichenoid reaction, glossitis and cheilitis, a dominantly mixed metal sensitisation pattern was typical, while in the subgroup of facial oedema/urticaria, subjective complaints and pre-implantation, nonspecific hypersensitivity pattern.
Metals were the most frequent dental contact allergens, but comprehensive oral screening series should also include non-metal allergens for diagnostic accuracy. 2-hydroxyethyl methacrylate was not a reliable screening marker for (meth)acrylates. The evaluation of the patch test until D7 is necessary. Patch testing without objective symptoms and positive history of allergic contact dermatitis was ineffective.
PMID:
42648905
Bibliographic data and abstract were imported from PubMed on 27 Aug 2026.
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