Lessons in conformational signalling: non-catalytic functions of protein kinase C isozymes.

Authors

Angus Cameron, Mathias Cobbaut, Veronique Calleja, Neil McDonald, Peter Parker

Published in

Philosophical transactions of the Royal Society of London. Series B, Biological sciences. Volume 381. Issue 1957. Aug 27, 2026.

Abstract

There is a growing literature describing non-catalytic functions of active protein kinases, reflecting the importance of these properties in the kinase repertoire. Here, we discuss recent work in this area relating to the kinase activity-independent oncogenic action of protein kinase C (PKC) alpha and draw parallels in relation with another PKC family member. We go on to illustrate some of the challenges in unpicking these non-catalytic properties with reference to the wider kinome, illustrating the issue that the wrong loss-of-function mutation may mislead. Finally, we comment on the opportunities these deeper insights bring. This article is part of the discussion meeting issue 'Epidermal growth factor receptor after 40 years'.

PMID:
42656143
Bibliographic data and abstract were imported from PubMed on 27 Aug 2026.

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