Multifaceted roles of phoenixin in polycystic ovary syndrome: a comparative study.

Authors

Sadinaz Akdu, Ummugulsum Can, Osman Ince

Published in

Revista da Associacao Medica Brasileira (1992). Volume 72. Issue 7. Pages e20252301. Epub Aug 21, 2026.

Abstract

Polycystic ovary syndrome is one of the most common endocrine disorders of reproductive-aged women worldwide. Phoenixin is a newly identified neuropeptide associated with reproductive functions and energy homeostasis. The aim of this study was to measure the serum levels of phoenixin-14 and phoenixin-20 in women with polycystic ovary syndrome versus controls and to investigate the relationship between phoenixin and polycystic ovary syndrome-related reproductive and metabolic disorders.
This study was performed in 36 women with polycystic ovary syndrome and 36 healthy women. The serum levels of phoenixin-14 and phoenixin-20 were measured by using the enzyme-linked immunosorbent assay method.
The serum phoenixin-14, phoenixin-20, luteinizing hormone, insulin levels, and homeostasis model assessment of insulin resistance values were higher in women with polycystic ovary syndrome compared to the control group (p<0.05). In contrast, follicle-stimulating hormone (p<0.01) levels in the polycystic ovary syndrome group were significantly lower than those of the control group, while testosterone levels were significantly higher than those of the controls (p<0.005). A significant positive correlation was found between serum phoenixin-14 and phoenixin-20 (r=0.605; p=0.001), insulin (r=0.458; p=0.012), and homeostasis model assessment of insulin resistance (r=0.453; p=0.014) in polycystic ovary syndrome groups. In polycystic ovary syndrome groups, serum phoenixin-14 was found to have a significant negative correlation with body mass index (r=-0.414; p=0.012). Phoenixin-20 levels correlated negatively with body mass index (r=-0.416; p=0.012) in polycystic ovary syndrome groups.
Phoenixin is dysregulated in polycystic ovary syndrome and is associated with metabolic parameters, warranting further mechanistic studies to elucidate its exact role.

PMID:
42659478
Bibliographic data and abstract were imported from PubMed on 28 Aug 2026.

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