Authors
Kittiya Supradit, Teva Phanaksri, Sattrachai Prasopdee, Sithichoke Tangphatsornruang, Duangjai Sangsrakru, Kanokpan Wongprasert, Montinee Pholhelm, Kritiya Butthongkomvong, Jutharat Kulsantiwong, Anthicha Kunjantarachot, Veerachai Thitapakorn
Published in
Asian Pacific journal of cancer prevention : APJCP. Volume 27. Issue 8. Pages 2871-2877. Aug 01, 2026. Epub Aug 01, 2026.
Abstract
To investigate plasma miR-1294 levels in cholangiocarcinoma (CCA) patients compared with healthy individuals and Opisthorchis viverrini-infected subjects.
To assess its potential as a plasma-based diagnostic biomarker, plasma samples were collected and total RNA was extracted from 15 healthy controls (HC), 12 O. viverrini (OV)-infected individuals, and 33 patients with CCA. miR-1294 expression was quantified using RT-qPCR (MiRXES).
Relative expression analysis demonstrated a significant upregulation of plasma miR-1294 in patients with CCA compared with both HC and OV groups (P < 0.0001). Receiver operating characteristic (ROC) curve analysis showed that miR-1294 discriminated CCA from non-CCA subjects, yielding an area under the curve (AUC) of 0.8676, with a specificity of 96.30% and a sensitivity of 63.64%.
The upregulation of plasma miR-1294 was investigated in this study. Despite these promising findings, the moderate sensitivity suggests that miR-1294 alone may not be sufficient as a standalone diagnostic marker. Nevertheless, its high specificity and non-invasive detectability highlight its potential utility as a complementary biomarker, particularly in combination with other diagnostic indicators for improved detection of CCA.
PMID:
42663208
Bibliographic data and abstract were imported from PubMed on 28 Aug 2026.
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