IFITM3 Is Elevated in BAL and Plasma Following Infection in ICU Setting.

Authors

Srabani Das, Carleen R Spitzer, Paul Consiglio, Matthew C Exline, Anasuya Sarkar

Published in

FASEB journal : official publication of the Federation of American Societies for Experimental Biology. Volume 40. Issue 17. Pages e72161. Sep 15, 2026.

Abstract

Interferon-induced transmembrane protein 3 (IFITM3) is an antiviral protein with emerging roles in regulating inflammatory pathways. Although much is known about the role of IFITM3 in mediating host antiviral defense, its contribution to systemic immune responses during critical infectious illnesses remains less understood. Here, we provide evidence that IFITM3 levels were significantly higher in cell free BAL fluid in septic patients with pulmonary infections and in circulating plasma extracellular vesicles (EVs) from critically ill septic patients compared to critically ill non-septic patients and healthy individuals. This study provides the first evidence of IFITM3's association with sepsis induced inflammatory responses and bacterial pulmonary infections, raising its potential as an agent of dysregulated immunity during systemic infection.

PMID:
42664046
Bibliographic data and abstract were imported from PubMed on 29 Aug 2026.

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