Multimodal biosensors: a review of signal synergy mechanisms, construction strategies, and application prospects.

Authors

Yuzhuo Lai, Ping Zhang, Yining Zhang

Published in

Analytical methods : advancing methods and applications. Aug 28, 2026. Epub Aug 28, 2026.

Abstract

The growing demand for accurate detection in complex matrices is promoting the transformation of multimodal biosensors from simple signal superposition to synergistic enhancement. This review systematically explains the mechanism underlying synergistic effects and identifies signal complementarity and anti-interference enhancement as the core features. The essence lies in the orthogonality and signal-linkage design of the detection principle. On this basis, the collaborative construction strategy of the trinity of "signal combination-nanomaterial-identification element" is proposed, and its differentiated adaptation patterns in biomedicine, food safety, and environmental monitoring are clarified. This review provides a theoretical framework and quantifiable evaluation basis for the rational design of high-performance multimodal biosensors.

PMID:
42664018
Bibliographic data and abstract were imported from PubMed on 29 Aug 2026.

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