High-density lipoprotein-related inflammatory indices and gynaecological cancer history: a cross-sectional analysis of NHANES.

Authors

Xiaoqin Yang, Sirong Cheng, Shanchen Wei, Xiaoxiao Liu, Wenxue Zhao, Ying Chu, Yali Huo

Published in

Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology. Volume 46. Issue 1. Pages 2721701. Epub Aug 28, 2026.

Abstract

Cross-sectional associations of high-density lipoprotein-related inflammatory indices (HIRIs) - white-blood-cell-, lymphocyte-, monocyte-, neutrophil-, and platelet-to-high-density lipoprotein cholesterol (HDL-C) ratios (WHR, LHR, MHR, NHR, and PHR) - with self-reported gynaecological cancer (GC) history are unclear.
We analysed 12,955 women from six National Health and Nutrition Examination Survey cycles (2007-2008 to 2017-March 2020 pre-pandemic), including 369 with GC history; cervical cancer (CC), 184; uterine cancer (UC), 127; and ovarian cancer (OC), 70. Primary analyses used survey-weighted logistic regression and restricted cubic spline (RCS) models with Benjamini-Hochberg false discovery rate (BH-FDR) correction; component-resolved and sensitivity analyses were supportive, and other secondary analyses were exploratory.
In fully adjusted models, overall GC history was nominally associated with PHR (odds ratio [OR] 1.26, 95% confidence interval [CI] 1.01-1.59; p = 0.045), the highest NHR tertile (OR 1.67, 95% CI 1.12-2.50; p = 0.013), and the highest WHR tertile (OR 1.56, 95% CI 1.04-2.34; p = 0.032). Subtype analyses showed selected nominal patterns, including an NHR tertile gradient for CC and WHR/LHR/PHR associations for UC; OC estimates were less stable. No primary logistic or RCS result survived BH-FDR correction. In supportive component-resolved analyses, the OC WHR white-blood-cell component met the BH-FDR threshold within the prespecified WHR-specific eight-test family (OR 2.40, 95% CI 1.35-4.25; p = 0.003; q = 0.025).
HIRIs showed modest, heterogeneous cross-sectional associations with self-reported GC history, but the primary findings were not retained after multiplicity correction. These ratios appear to reflect both shared HDL-C and numerator-cell information and should be interpreted as descriptive, hypothesis-generating phenotypes rather than diagnostic, prognostic, or causal markers.

PMID:
42665432
Bibliographic data and abstract were imported from PubMed on 29 Aug 2026.

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