Cisplatin-induced sarcoidosis-like reaction after primary chemoradiotherapy for locally advanced cervical cancer.

Authors

Susan Healsmith, Leon Foster, Jennifer Chard, Alison Brand

Published in

BMJ case reports. Volume 19. Issue 8. Aug 28, 2026. Epub Aug 28, 2026.

Abstract

A woman in her mid-40s presented with post-coital bleeding and a squamous cell carcinoma of the cervix was identified. Initial investigation identified a primary fluorodeoxyglucose positron emission tomography (FDG PET)-avid lesion and avid external iliac lymph nodes (stage IIIC1). She was planned for primary chemoradiation treatment with curative intent.Treatment included external beam radiation therapy, brachytherapy and weekly cisplatin. A follow-up FDG PET found a partial metabolic response within the cervix. It also identified interval development of FDG-avid lymph nodes in the periportal lymphatics in the abdomen, mediastinal and bilateral hilar lymph nodes, 8 vertebrae and iliac bones. Biopsy confirmation was attempted and hilar lymph nodes were suggestive of granulomatous inflammation.A final diagnosis of cisplatin-induced sarcoidosis-like reaction was made. No treatment was initiated. A follow-up FDG PET 3 months later found ongoing response of the primary lesion and complete resolution of the reactive sarcoidosis-like reaction.

PMID:
42665296
Bibliographic data and abstract were imported from PubMed on 29 Aug 2026.

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