Co-evolution of science and ethics in the clinical translation of nanocarriers for oncology: A perspective.

Authors

Sobia Noreen

Published in

Nanomedicine : nanotechnology, biology, and medicine. Pages 103015. Aug 28, 2026. Epub Aug 28, 2026.

Abstract

The journey of advanced nanomaterials, including nanocarrier-based therapeutics, has significantly transformed oncology by improving drug targeting, therapeutic delivery, biodistribution, and efficacy. However, the rapid clinical transition of emerging nanotechnology into clinical practice has introduced bioethical, regulatory, and social challenges that extend beyond the conventional biomedical paradigm. The current perspective argues that applying traditional bioethical principles, such as respect for persons, beneficence, non-maleficence, and justice, is challenged by the unique physicochemical characteristics of nanocarriers during the clinical transition from bench to bedside. Key issues discussed are informed consent, patient understanding, long-term safety, equitable accessibility, accountability, regulatory oversight, and post-marketing surveillance. In addition, the discussion proposes a co-responsibility approach in which patients, researchers, clinicians, industry regulatory authorities, and society collectively participate in the ethical transition process. Moreover, a co-evolutionary approach is suggested, in which innovation, ethics, regulation, and clinical applications will develop together.

PMID:
42665200
Bibliographic data and abstract were imported from PubMed on 29 Aug 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.