Authors
Mingyue Zhou, Jin Lan, Tianyang Zhang, Zhiyong Li, Chongyang Ou, Jun Xiong, Juan Su, Shuai Yan
Published in
Journal of pharmaceutical analysis. Volume 16. Issue 9. Pages 101551. Epub Jan 11, 2026.
Abstract
Ferroptosis is a cell death mode caused by excessive accumulation of lipid peroxides (LPOs) due to intracellular metabolic pathway disorder, which is closely related to intracellular iron metabolism and lipid homeostasis. In cancer therapy, this metabolic imbalance promotes the clearance of tumor cells, suggesting that ferroptosis exerts a tumor suppressor function. However, the clinical translation of ferroptosis-based strategies in oncology is currently hindered by challenges such as inadequate therapeutic efficacy. In the past five years, the rational design of nano-formulations to induce cancer ferroptosis combined with other emerging therapeutic modalities (chemotherapy (CT), chemodynamic therapy (CDT), photodynamic therapy (PDT), sonodynamic therapy (SDT), and immunotherapy) has achieved promising therapeutic effects in many rodent tumor models. This review summarizes the recent progress of novel nano-formulations for cancer ferroptosis therapy. The multiple mechanisms and detection indicators of cancer cells during ferroptosis, the rational design of novel nano-formulations, and their strategies for inducing cancer ferroptosis will be introduced. Finally, the challenges and prospects of utilizing novel nano-formulations for cancer ferroptosis therapy will be discussed.
PMID:
42666523
Bibliographic data and abstract were imported from PubMed on 29 Aug 2026.
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