Transcatheter tricuspid valve replacement for severe tricuspid regurgitation: current and future perspectives.

Authors

Gianmaria Calamita, Pier Pasquale Leone, Ossama Elsaid, Matteo Sturla, Syed Rizvi, Jacopo Lin, Tadahisa Sugiura, Andrea Scotti, Aryeh Abelow, Manaf Assafin, Edwin Ho, Azeem Latib

Published in

Expert review of medical devices. Aug 29, 2026. Epub Aug 29, 2026.

Abstract

Severe tricuspid regurgitation (TR) is common, undertreated, and associated with significant morbidity and mortality. Transcatheter tricuspid valve replacement (TTVR) has emerged as a promising option for patients unsuitable for surgical repair or transcatheter edge-to-edge repair.
This review examines the innovation trajectory, current device landscape, patient selection, imaging guidance, procedure-specific challenges, and future perspectives of TTVR. A systematic literature search was performed using PubMed/MEDLINE, Embase, and ClinicalTrials.gov, covering publications from January 2015 to May 2025, using search terms including 'transcatheter tricuspid valve replacement,' 'TTVR,' 'tricuspid regurgitation,' and device-specific names.
TTVR offers near-complete regurgitation elimination but remains anatomy- and mechanism-dependent. Its role is best defined in patients with anatomy unfavorable for repair. Optimal timing, device selection, antithrombotic management, and long-term durability require prospective validation through dedicated trials and head-to-head comparisons with repair strategies.

PMID:
42667674
Bibliographic data and abstract were imported from PubMed on 30 Aug 2026.

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