Arginine-engineered gold nanoclusters for doxorubicin chemiluminescence sensing.

Authors

Chuangui Cai, Zhen Lin, Wensong Yao, Shan Lian, Kaiyuan Huang, Haohua Deng, Xinhua Lin, Wei Chen

Published in

Mikrochimica acta. Volume 193. Issue 9. Aug 29, 2026. Epub Aug 29, 2026.

Abstract

Arginine surface-engineered 6-aza-2-thiothymine gold nanoclusters (Arg/ATT-AuNCs) via host-guest assembly were synthesized which exhibit exceptional catalytic activity and intense photoluminescence. Arg/ATT-AuNCs enhanced the CL intensity from NaIO₄-H₂O₂ system by 1200-fold. The CL mechanistic studies revealed that Arg/ATT-AuNCs not only accelerated decay of H₂O₂ to form reactive oxygen species, but also acted as efficient energy acceptors of singlet oxygen (¹O₂) via a CL resonance energy transfer (CRET) pathway. It was observed that doxorubicin (DOX) quenches the CL signal through an inner filter effect that disrupts the CRET process. Based on this, a straightforward, rapid, and highly sensitive biosensor has been developed for the detection of DOX in human serum samples, achieving a low detection limit of 0.029 µM. The biosensor was applied to DOX determination in human serum samples with recoveries ranging from 91.1 to 106.2%. This study not only provides a new method for the detection of DOX, but also broadens the application scope of AuNCs in the field of CL.

PMID:
42667424
Bibliographic data and abstract were imported from PubMed on 30 Aug 2026.

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