Authors
Shaofei Yan, Ke Wu, Meng Zhang, Dongmei Tan, Li Zhan, Bosheng Li, Xiaorong Yang, Zushun Yang, Weiwei Li, Yunchang Guo, Changwei Lei
Published in
Food microbiology. Volume 141. Pages 105236. Epub Jul 13, 2026.
Abstract
Nontyphoidal Salmonella (NTS) is a leading zoonotic bacterial pathogen and a major cause of foodborne illness worldwide. Salmonella enterica subsp. enterica serovar Corvallis (S. Corvallis) has recently emerged in China as a serotype of concern, showing an elevated antimicrobial resistance (AMR) profile. We analyzed 260 S. Corvallis isolates collected through the China National Foodborne Disease Surveillance Program between 2014 and 2023, together with 598 publicly available genomes from global sources. Antimicrobial resistance determinants, pan-genome dynamics, phylogenetic structure, and patterns of global dissemination were characterized in an integrated framework. Isolates from the chicken production chain (chicken meat and slaughter-environment samples) harbored significantly more AMR genes (ARGs) than those of human origin. Correlation network analysis revealed consistent associations between specific plasmid replicons and ARGs: IncHI2 co-occurred with aadA16, dfrA27, and sul1; IncQ1 with floR; and IncA/C2 with dfrA12 and aadA2, with IS26 likely mediating their co-mobilization. SNP analysis demonstrated genetic distances ranging from 0 to 350 SNPs between isolates, with a substantial proportion showing ≤10 SNP differences, suggesting potential transmission events. Geographically, strains clustered predominantly around China, the United Kingdom, and countries in the Americas, with ST1541 as the dominant sequence type. Transmission inference further highlighted strong cross-regional links between UK and Chinese isolates. The co-occurrence of China-enriched ARGs with specific mobile genetic elements (MGEs) supports an evolutionary scenario in which a highly virulent, multidrug-resistant S. Corvallis clade has emerged through the combined effects of cross-regional dissemination and MGE-driven horizontal gene transfer, plausibly shaped by localized antimicrobial selection pressure. These findings underscore how regional antimicrobial use practices, particularly within the poultry production chain, can shape the evolution of resistant zoonotic pathogens with global transmission potential, and argue for coordinated One Health surveillance of emerging NTS serotypes.
PMID:
42668177
Bibliographic data and abstract were imported from PubMed on 30 Aug 2026.
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