Ai-based multimodal analysis of ECG and clinical data for evaluation for competitive sports participation: The VALETUDO trial.

Authors

Marchetti Davide, Taconné Marion, Conte Edoardo, Quaglia Francesca, Provera Andrea, Gallazzi Michele, Paolisso Pasquale, Melotti Eleonora, Schillaci Matteo, Bartorelli Antonio, Corino Valentina, Cerveri Pietro, Zeppilli Paolo, Mainardi Luca, Andreini Daniele

Published in

International journal of cardiology. Pages 134744. Aug 29, 2026. Epub Aug 29, 2026.

Abstract

Pre-participation cardiovascular screening (PPS) is essential for preventing SCD in athletes, yet ECG interpretation requires expertise and remains resource-intensive. We aimed to evaluate the feasibility and diagnostic performance of a deep learning (DL) model for analysis of clinical data and resting 12‑lead ECG obtained during routine PPS in competitive athletes.
In this prospective single center observational study, competitive athletes aged 18 to 60 years and undergoing routine PPS were enrolled. PPS included medical history, physical examination, resting and exercise ECG. Athletes were classified as fit or not fit for competitive sports according to clinical evaluation. Resting ECG and clinical variables were analyzed using a multimodal DL architecture. Model performance was assessed using stratified 10-fold cross-validation against PPS clinical classification.
A total of 526 athletes were enrolled (72% male, median age of 27 years (IQR: 20-41); 166 (32%) had a negative PPS result. The test setting (10-fold cross-validation), the model achieved moderate discrimination with an accuracy of 0.64 ± 0.08, SE 0.68 ± 0.15, SP 0.61 ± 0.17, F1-score 0.72 ± 0.1, PPV 0.80 ± 0.07, NPV 0.48 ± 0.12, AUC 0.72(0.66-0.78). Training performances reached accuracy of 0.70 ± 0.06, SE 0.73 ± 0.12, SP 0.67 ± 0.14, F1-score 0.77 ± 0.07, AUC 0.79 (0.74-0.83.
Automated DL-based analysis of 12‑lead ECG during PPS is feasible and showed encouraging diagnostic performance in competitive athletes. Although wider experience and external validation is required, AI-assisted multimodal ECG interpretation may represent a useful adjunct to physician assessment for cardiovascular risk stratification in sport screening programs.

PMID:
42668095
Bibliographic data and abstract were imported from PubMed on 30 Aug 2026.

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