Authors
Ganesh H Ghanwat, Anup S Hendre, Ajit V Sontakke, Bhagyashri Yadav, Rohan S Phatak, Amar R Mohite
Published in
Caspian journal of internal medicine. Volume 17. Issue 2. Pages 422-428. Epub Mar 10, 2026.
Abstract
The prevalence of abdominal obesity is increasing rapidly worldwide and is a leading cause of morbidities and mortalities. Abdominal obesity is associated with various health complications including insulin resistance (IR), type 2 diabetes etc. The present research studied the outcome of VC intake on adiponectin (ACRP30) levels and its relationship with waist circumference (WC) and IR.
The present study was carried out on a total of 80 subjects. 42 obese (20 males and 22 females) and 38 non-obese (19 males and 19 females) were enrolled into two groups. Vitamin C (500 mg) was provided to all study subjects and instructed to consume it three times a day over a period of 90 consecutive days. Fasting blood samples were collected at the baseline and end of the study. Adiponectin levels were measured. Data were analyzed by using a two-tailed Student's t-test.
Vitamin C supplementation significantly increased serum adiponectin (ACRP30) levels in obese males (P = 0.0485), obese females (P = 0.0235), non-obese males (0.0457), and non-obese females (0.0245). Adiponectin is inversely correlated with WC and IR. No significant differences were found in the levels of serum adiponectin between study participants gender-wise.
500 mg of vitamin C intake, three times a day for 90 days, is a novel potential therapeutic approach to restore the capacity of adipose tissue in secreting adiponectin and for the treatment of abdominal obesity and allied complications.
PMID:
42668856
Bibliographic data and abstract were imported from PubMed on 30 Aug 2026.
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