Authors
Nilla Sari Ngadi, Hiroko Sonoda, Mizuho Uematsu, Masahiro Yasuda, Shoichi Wakitani, Yoshiki Higashijima, Masahiro Ikeda
Published in
The Journal of veterinary medical science. Aug 31, 2026. Epub Aug 31, 2026.
Abstract
Serotonin (5-HT) regulates gastrointestinal (GI) motility by activating various 5-HT receptor (5-HTR) subtypes. However, the expression and distribution of 5-HTR subtypes in the GI tract of Japanese Black cattle under both healthy and diseased conditions remain largely unknown. This study examined the expression of seven-transmembrane 5-HTR subtypes in healthy and fat necrosis (FN)-affected Japanese Black cattle. We found clear expression of 5-HT1BR, 5-HT2BR, 5-HT4R, and 5-HT7R mRNAs in the GI tract, in both young and adult groups. Expression of 5-HT4R and 5-HT7R was higher at most sites in adult cattle than in young cattle. The highest 5-HT4R expression was observed in the colon of adult cattle. Given the availability of antibodies and use of 5-HT4R agonists in therapy, we further examined the localization of 5-HT4R. We detected 5-HT4R mRNA and protein in neurons of the myenteric and submucosal plexuses. In FN-affected cattle, expression of 5-HT1BR, 5-HT2BR, and 5-HT7R mRNAs tended to decrease in the GI tract, while 5-HT4R mRNA remained unchanged, in comparison with healthy adult cattle. Our results show that 5-HT1BR, 5-HT2BR, 5-HT4R, and 5-HT7R mRNAs are obviously expressed in the GI tracts of Japanese Black cattle. Because 5-HT4R mRNA expression did not differ between healthy and FN-affected cattle, 5-HT4R agonists may offer therapeutic benefits for both groups, suggesting potential for clinical application in Japanese Black cattle.
PMID:
42669519
Bibliographic data and abstract were imported from PubMed on 31 Aug 2026.
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