Asymmetric synthesis of fused seven-membered chromanones from 3-hydroxy chromones and vinyl ethylene carbonates.

Authors

Hongjia Xie, Zongli Xiong, Weijun Yao, Wenling Qin, Zhen Wang

Published in

Organic & biomolecular chemistry. Aug 31, 2026. Epub Aug 31, 2026.

Abstract

A practical and efficient protocol for the enantioselective synthesis of seven-membered fused chromanone derivatives has been developed under mild conditions. This approach proceeds via a stepwise sequence involving a palladium-catalyzed O-allylic reaction of 3-hydroxy chromones with vinyl ethylene carbonates, followed by a copper-promoted asymmetric [1,3]-rearrangement/hemiketalization cascade. The method exhibits broad substrate tolerance, affording the new chromanone products in moderate yields with excellent enantio- and diastereoselectivities (19-76% yield, 89-97% ee, >19 : 1 dr).

PMID:
42669419
Bibliographic data and abstract were imported from PubMed on 31 Aug 2026.

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