Clinical Diagnosis and Treatment Analyses on Dedifferentiated Liposarcoma of the Head and Neck: A Single-Center Experience With Systematic Review of the Literature.

Authors

Xinyu Li, Qian Shi, Hongzhi Ma, Ling Feng, Shizhi He, Lingwa Wang, Haiyang Li, Jugao Fang, Ru Wang

Published in

The Journal of craniofacial surgery. Aug 28, 2026. Epub Aug 28, 2026.

Abstract

The aim of this study was to report 2 cases of dedifferentiated liposarcoma (DDLPS) in the peripharyngeal space and review the relevant literature to summarize its clinical and histopathologic features and therapeutic approaches, especially operative selection and prognosis.
A comprehensive review of the literature was performed in January 2025 to identify relevant articles using the PubMed database. Sixty patients were included in this study: 2 new cases from Beijing Tongren Hospital in 2018 and 2023, and 58 previously reported cases that occurred between 1979 and 2024 from a systematic review of the literature. We analyzed and summarized the patients' epidemiological data, clinical features, and treatment regimens. The main outcomes were overall survival (OS) and recurrence-free survival (RFS).
DDLPS was approximately twice as common in men as in women, with a median age of 61 years (range: 20-86 y). MDM2 amplification was positive in 13 patients (13/14, 92.9%). Nearly all the patients underwent surgical excision (35/36, 97.2%). Almost half of the patients (17/36, 47.2%) underwent surgery with postoperative radiotherapy (RT). The 1-year, 3-year, and 5-year OS rates were 91.3%, 81.2%, and 81.2%, respectively. The 1-year, 3-year, and 5-year RFS rates were 91.3%, 74.9%, and 64.2%, respectively. Local radical excision is the preferred treatment modality for DDLPS. Adjuvant chemoradiotherapy after radical surgery resection had no statistically significant impact on OS or RFS (P˃0.05).
Detection of MDM2 during initial biopsy can prevent delays in diagnosis and treatment. Local radical excision is the preferred treatment modality for DDLPS.

PMID:
42669453
Bibliographic data and abstract were imported from PubMed on 31 Aug 2026.

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