Authors
Junqi Liao, Jie Yang, Yuanyuan Zhao, Zhiquan Tang, Min Wang, Shuting Jiang, Mingming Fang, Hongquan Liu
Published in
Diabetes research and clinical practice. Pages 113541. Aug 30, 2026. Epub Aug 30, 2026.
Abstract
The associations and comparative discrimination of indices integrating inflammation, insulin resistance, and body shape within glycemic-status strata remain uncertain.
We included 13,867 adults from the 1999-2010 and 2015-2018 National Health and Nutrition Examination Survey. Complex-survey weighted Cox models evaluated CTI, CTI-BMI, CTI-BRI, CTI-WWI, CTI-ABSI, and CTI-WHtR continuously and by weighted quartiles in participants with normal glycemia, abnormal glycemia, or diabetes. Restricted cubic splines, time-dependent receiver operating characteristic curves, interaction tests, and sensitivity analyses were performed.
During follow-up, 2,197 all-cause and 687 cardiovascular deaths occurred. Among participants with abnormal glycemia, the hazard ratios per weighted standard deviation for CTI-ABSI were 1.21 (95 % CI, 1.10-1.34) for all-cause mortality and 1.43 (95 % CI, 1.18-1.73) for cardiovascular mortality. Corresponding estimates for CTI-WWI were 1.19 (95 % CI, 1.07-1.33) and 1.49 (95 % CI, 1.20-1.85). CTI-ABSI and CTI-WWI had relatively higher single-marker AUCs in several analyses, but incremental improvements beyond clinical factors were small. Glycemic-status interactions were not statistically significant.
Several CTI-related indices were associated with mortality within glycemic-status strata. However, the findings do not establish effect modification, group-specific applicability, or validated clinical utility. These indices should be considered epidemiological markers.
PMID:
42669380
Bibliographic data and abstract were imported from PubMed on 31 Aug 2026.
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