Authors
Xinyi Huang, Wenqin Che, Wenhui Wang, Baoxiang Kang, Xiaolei Liu, Juan Li, Zaizhu Lou, Baojun Li
Published in
ACS sensors. Aug 24, 2026. Epub Aug 24, 2026.
Abstract
Enantiomeric discrimination of chiral metabolites is crucial for disease diagnosis and drug screening. Herein, a chiral plasmonic cavity configuration was constructed by coupling helical Au nanorod (AuNRs) with an Au film (AuF) for enantioselective surface-enhanced Raman scattering (SERS) recognition. The optimized chiral AuNRs/AuF cavity substrate creates strong localized hotspots with defined handedness, leading to significantly boosted Raman signals with an enhancement factor of 1.2 × 108 and amplified chiral discrepancy. Quantitatively, the substrate achieves a chiral discrimination ability of 74.0%, and a detection limit of 10-8 M for L-phenylalanine. The combined experimental and theoretical results demonstrate that the superior enantioselectivity originates from the cooperative effect between chiral plasmonic field localization and stereospecific molecular interaction. As a proof of concept, the proposed chiral AuNRs/AuF substrates realized real-time quantitative detection of a chiral drug metabolite in human sweat, allowing dynamic monitoring of an individual's metabolic profile. This work provides a novel strategy for developing advanced biosensing chips suitable for sensitive detection of disease-related chiral molecules, with great potential in diagnosis, prognosis, and personalized medicine.
PMID:
42673366
Bibliographic data and abstract were imported from PubMed on 01 Sep 2026.
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