Pharmacologic Treatment for Migraine Prevention in Adults Practice Guideline Recommendations: Report of the AAN Guidelines Subcommittee and the American Headache Society.

Authors

Sonja Potrebic, Sarah Tanveer, Werner J Becker, Rebecca Burch, Lara J Cooke, Todd Fenton, Jeff J Fletcher, Gillian L Gordon Perue, Andrew D Hershey, Jeffrey L Jackson, Shirley Kessel, Elizabeth W Loder, Mia T Minen, Maryam Oskoui, Vijay K Ramanan, Michelle Murren, Todd J Schwedt, Stephen D Silberstein, Don B Smith, Kylie A Botchway-Doe, Heather M Silsbee, Tamara Pringsheim

Published in

Neurology. Volume 107. Issue 7. Pages e214881. Oct 13, 2026. Epub Aug 31, 2026.

Abstract

This practice guideline provides updated evidence-based recommendations regarding the use of pharmacologic migraine prevention in adults. A multidisciplinary panel conducted a systematic review and developed practice recommendations following the process outlined in the 2017 edition of the American Academy of Neurology Clinical Practice Guideline Process Manual. The systematic review includes studies published through June 6, 2024, and is available in a companion publication. Recommendations are supported by structured rationales that integrate evidence from the systematic review, related evidence, principles of care, and inferences from evidence. Recommendations are provided on how to decide when it is appropriate to start a pharmacologic migraine preventive medication and how to decide which migraine preventive medication to start. Recommendations address decision making on appropriate choices of migraine preventive medications in specific situations and populations, including patients with fibromyalgia, obesity, or hypertension; considerations for older adults; treatment during pregnancy and lactation; sex-related factors in choosing medications; and treatment for patients with medication overuse. Recommendations on assessment of treatment efficacy, adverse effects, and discontinuing migraine preventive medications are provided.

PMID:
42673560
Bibliographic data and abstract were imported from PubMed on 01 Sep 2026.

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