Authors
Nam-Kyu Choi, So-Woon Kim, Dong-Hoon Kim, Sung-Im DO, Hidetaka Yamamoto, Kiyong Na
Published in
Anticancer research. Volume 46. Issue 9. Pages 5289-5299.
Abstract
Dedifferentiated liposarcoma (DDL) is defined by amplification of chromosome 12q13-15 but exhibits substantial morphologic heterogeneity, including variable stromal composition. This study aimed to determine whether prominent stromal patterns in DDL are associated with distinct immunophenotypic and genomic profiles.
Nineteen surgically resected DDLs were evaluated for histologic features, immunophenotype, and targeted genomic alterations using next-generation sequencing. Associations between stromal pattern, immunohistochemistry, copy number alterations, and clinical outcome were analyzed.
All cases demonstrated MDM2 amplification and strong nuclear MDM2 expression, with frequent co-amplification of CDK4. Beyond canonical 12q alterations, recurrent amplifications were identified, including 1q23 (DDR2), 5p15 (TERT), and 12q13 (STAT6). Notably, DDR2 amplification was significantly enriched in collagenous-dominant DDLs compared with myxoid-dominant tumors. Stromal pattern correlated with immunophenotype, with collagenous-dominant tumors showing frequent SMA expression and absence of CD34, whereas myxoid-dominant tumors more frequently expressed CD34. High mitotic activity and mFNCLCC grade 3, but not stromal pattern, were associated with adverse outcome.
Prominent stromal patterns in DDL reflect biologically meaningful subsets associated with distinct immunophenotypic features and secondary genomic alterations. In particular, enrichment of DDR2 amplification in collagenous-dominant DDL suggests a potential link between collagen-associated signaling pathways and stromal morphogenesis in this tumor.
PMID:
42674680
Bibliographic data and abstract were imported from PubMed on 01 Sep 2026.
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