Lesion-level Quantitative Post-therapy SPECT/CT During ¹⁷⁷Lu-DOTATATE PRRT for NET Liver Metastases.

Authors

Kenta Konishi, Kohei Wakabayashi, Tsutomu Ikenohira, Rintaro Yamashita, Shuhei Aramaki, Shun Ito, Katsumasa Nakamura

Published in

Anticancer research. Volume 46. Issue 9. Pages 5301-5309.

Abstract

Quantitative post-therapy single-photon emission computed tomography/computed tomography (SPECT/CT) may offer valuable insights for response assessment during peptide receptor radionuclide therapy (PRRT), but lesion-level evidence for liver metastases from neuroendocrine tumors (NETs) remains limited. This study assessed lesion-level longitudinal changes in practical quantitative indices, including kBq/ml max and maximum standardized uptake value (SUVmax), during ¹⁷⁷Lu-DOTATATE PRRT and their association with CT-based volumetric change.
This retrospective single-center study included 12 patients with NETs (51 liver metastases) treated with ¹⁷⁷Lu-DOTATATE PRRT. Quantitative SPECT/CT was performed the day after each cycle. SUVmax and kBq/ml max were measured for each lesion, and tumor volume was assessed using the CT component. Baseline (post-cycle 1) and final-cycle values were recorded. Lesions were classified as non-progressive (shrinkage/disappearance/stable) or progressive based on CT volumetric change. Spearman's rank correlation, the Wilcoxon signed-rank test, and the Mann-Whitney U-test were used.
Eleven patients completed four cycles and one discontinued after three cycles. Lesion volume, kBq/ml max, and SUVmax significantly decreased from baseline to final evaluation (all p<0.01). Of 51 lesions, 39 were non-progressive and 12 were progressive. Percentage reductions in kBq/ml max and SUVmax were strongly correlated with volumetric shrinkage (ρ=0.757 and 0.734). Non-progressive lesions showed greater reductions in both indices than progressive lesions (both p<0.01). Baseline kBq/ml max and SUVmax were higher in non-progressive lesions (p=0.029 and 0.030).
In this exploratory lesion-level analysis for NET liver metastases, post-therapy quantitative SPECT/CT metrics (kBq/ml max and SUVmax) were associated with CT-based volumetric change during ¹⁷⁷Lu-DOTATATE PRRT.

PMID:
42674685
Bibliographic data and abstract were imported from PubMed on 01 Sep 2026.

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