Sequential Changes in Right Ventricular Straein During the Development of Pulmonary Hypertension Assessed With Magnetic Resonance Feature Tracking: An Animal Study.

Authors

Na Young Kim, Dong Jin Im, Yoo Jin Hong, Ji Won Lee, Chul Hwan Park, Ji Ye Jung, Jin Gu Lee, Hye-Jeong Lee

Published in

Korean journal of radiology. Sep 01, 2026. Epub Sep 01, 2026.

Abstract

To evaluate the sequential changes in right ventricular (RV) strain and histological vascular remodeling and their correlations during pulmonary hypertension (PH) development in a rat model by using cardiac magnetic resonance (CMR)-feature tracking (FT).
Separate cohorts of six-week-old male Wistar rats (10 per group) were allocated to a baseline group, PH induction groups assessed at 1, 2, 3, or 4 weeks after monocrotaline injection, and vehicle-injected control groups assessed at 2 and 4 weeks. Each rat underwent a single magnetic resonance imaging (MRI) examination and was subsequently euthanized for histological analysis. Cine images were acquired using a 9.4T MRI scanner, and strain was analyzed using the FT technique. Histological analysis was used to quantify pulmonary arterial wall thickness percentage (PA %WT) and RV collagen density. Overall group differences were analyzed using the Kruskal-Wallis test, which was followed by the Mann-Whitney U test with Bonferroni correction for pairwise comparisons with the baseline group. Correlations between the variables were assessed using Spearman's correlation coefficients.
All CMR-derived RV parameters showed significant differences across the baseline and PH induction groups (all P < 0.001). RV free wall longitudinal strain (RVFWLS) showed the earliest impairment at 2 weeks, with a progressive decline thereafter. The RV free wall circumferential strain (RVFWCS) and RV ejection fraction were reduced beginning at 3 weeks, whereas the RV end-diastolic volume index increased significantly only at 4 weeks. The PA %WT increased progressively from week 2, whereas the RV collagen density did not change significantly. RVFWLS and RVFWCS showed strong positive correlations with PA %WT (r = 0.885 and r = 0.757, respectively; both P < 0.001), which were primarily driven by parallel changes across the post-induction time points. The control groups showed no significant temporal changes in the CMR or histological measurements.
In this preclinical model of PH, staged CMR and histological assessments demonstrated sequential RV remodeling in parallel with PA remodeling, with RVFWLS impairment preceding overt RV dysfunction and enlargement.

PMID:
42676173
Bibliographic data and abstract were imported from PubMed on 01 Sep 2026.

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