Authors
Fang Shi, Shuo Tang, Yuqing Wang, Xinyuan Feng, Liuyun Jiang
Published in
Macromolecular bioscience. Volume 26. Issue 9. Pages e70250.
Abstract
Lignin's intrinsic fluorescence and bioactivities (antioxidant, antibacterial, photoprotective) arise directly from its polyphenolic macromolecular architecture. This review critically integrates lignin-based fluorescent polymers for intelligent bone regeneration, bridging lignin photophysics and tissue engineering. We dissect the macromolecular origins of lignin's biological modalities and its aggregation-induced emission (AIE) behavior, where clustering of phenylpropanoid units transforms concentration quenching into a luminescent design advantage. Synthetic strategies that employ lignin as macromonomers, initiators, and crosslinkers to fabricate fluorescent polymers with tunable optics and preserved bioactivity are surveyed. We highlight two emerging applications: non-invasive, real-time tracing of scaffold degradation via intrinsic fluorescence, and integrated theranostics that synergize antibacterial defense, oxidative stress modulation, and pro-osteogenic induction within a single macromolecular system. Critically, we identify five translational bottlenecks-heterogeneity-driven photophysical variability, insufficient quantum yield, long-term chromophore biosafety, multifunctionality‑processability trade-offs, and batch‑to‑batch fluorescence inconsistency-and propose chemical and processing strategies to overcome them. By merging lignin macromolecular chemistry, fluorescence photophysics, and bone biology, we position lignin-based fluorescent polymers as a distinct bioactive class where therapeutic function is programmed into the polymer backbone, offering a promising paradigm for macromolecular design.
PMID:
42675909
Bibliographic data and abstract were imported from PubMed on 01 Sep 2026.
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