Chromium-catalyzed chemo- and regioselective synthesis of allenes from propargylic pivalates with Grignard reagents.

Authors

Zheng Luo, Yihui Zou, Xiaoting Zhang, Xingsheng Li, Xiaoming Zeng

Published in

Chemical communications (Cambridge, England). Sep 01, 2026. Epub Sep 01, 2026.

Abstract

We report here an effective and practical pathway for the chromium-catalyzed chemo- and regioselective synthesis of allenes under ligand-free and mild conditions. This reaction utilized low-cost CrCl₂ as the precatalyst, combined with easily available propargylic pivalates and Grignard reagents, a variety of allenes bearing a wide range of functional groups have been obtained with excellent yields in the absence of an external ligand.

PMID:
42676181
Bibliographic data and abstract were imported from PubMed on 01 Sep 2026.

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