Beyond the ceiling: A critical analysis of microRNA research in cutaneous T-cell lymphoma and a roadmap forward.

Authors

Maria Gluud, Chella K Vadivel, Martin R J Namini, Ziao Zeng, Lang Yan, Sana Ahmad, Charlotte Menne Bonefeld, Carsten Geisler, Lise-Mette Rahbek Gjerdrum, Emmanuella Guenova, Terkild B Buus, Thomas Litman, Niels Ødum

Published in

The Journal of investigative dermatology. Sep 01, 2026. Epub Sep 01, 2026.

Abstract

MicroRNAs (miRNAs) have been studied in cutaneous T-cell lymphoma (CTCL) for more than 15 years, revealing oncogenic and tumor-suppressive networks, the JAK/STAT-miRNA signaling circuit, diagnostic classifiers, and therapeutic miRNA targeting (Cobomarsen, targeting miRNA-155). Yet, no miRNA diagnostic has reached clinical practice. We synthesize the CTCL miRNA literature and argue that translation has stalled as a result of 2 interrelated limitations-methodological and biological-including reliance on bulk-tissue profiling and the intrinsic miRNA biology, including modest regulation of multiple pathways. Future strategies encompassing single-cell and subclone profiling, targeted anti-miRNA delivery, multiomics integration, miRNA network remodeling, multicenter validation, and artificial intelligence-driven bioinformatics may herald a golden renaissance for miRNAs.

PMID:
42678334
Bibliographic data and abstract were imported from PubMed on 01 Sep 2026.

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