Ovarian puncture alters genes but not follicle growth in cyclophosphamide mice model.

Authors

Camila Stefane Ferreira, Luiza Aparecida Ansaloni Chagas Pereira, Stella Pollyanne de Oliveira, João Pedro Lobão Gomes de Castro, Vanessa Neves Guimarães, Patrick de Abreu Barbosa, Jade Carceroni de Sousa Carvalho, Ana Maria Alvarenga Fagundes, Antonio Sergio Varela Junior, Carine Dahl Corcini, Erika Cristina Jorge, Paulo Henrique Almeida Campos-Junior

Published in

Reproduction & fertility. Aug 31, 2026. Epub Aug 31, 2026.

Abstract

Infertility is a concern for cancer patients who wish to conceive after completing chemotherapy treatment. Puncturing the ovary is part of the IVF procedure, aimed at collecting eggs to fertilize and transferring them to the uterus. We decided to study whether the inflammation and tissue damage caused by puncturing the ovaries could stimulate the collection of healthy eggs in patients who have gone through chemotherapy. To this end, we used female mice that were treated with a frequently used treatment for breast cancer, along with ovarian puncture. We discovered the alterations did not affect follicle growth or egg retrieval. With these findings, we demonstrated, for the first time, the ability of ovarian puncture to bring about healthy egg retrieval, improving quality of life after cancer.

PMID:
42677808
Bibliographic data and abstract were imported from PubMed on 01 Sep 2026.

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