Assessment of NGAL, eGFR, and tubular injury markers for early detection of chemotherapy-induced nephrotoxicity in pediatric oncology patients.

Authors

Petya Markova, Antoniya Yaneva, Mariya Spasova, Stoyan Markov, Kostadin Kostadinov

Published in

Folia medica. Volume 68. Issue 4. Aug 31, 2026.

Abstract

Acute kidney injury is a common complication in children with oncological diseases. Its etiology is multifactorial, with key risk factors including drug-induced nephrotoxicity, tumor lysis syndrome, and infection-including sepsis during periods of aplasia. The classical diagnostic criteria for AKI rely on monitoring serum creatinine levels and detecting oliguria. In the context of drug-induced nephrotoxicity, the predominant pathophysiological mechanism is tubular injury, which is typically non-oliguric and may not cause changes in serum creatinine, even in cases of severe damage.

PMID:
42677770
Bibliographic data and abstract were imported from PubMed on 01 Sep 2026.

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