Periorbital cholesterol granulomas/cysts - two clinical cases presentation.

Authors

Karen Dzhambazov, Stoyan Markov, Aleksandrina Topalova-Shishmanova, Georgi Georgiev, Konstantin Giritliev, Elizabet Dzhambazova

Published in

Folia medica. Volume 68. Issue 2. Mar 19, 2026.

Abstract

Cholesterol granulomas and cysts represent uncommon pathological findings in the paranasal cavities; however, they have also been documented in other areas, including the orbit, the petrous part of the temporal bone, and the nasal septum, among others. Histologically, they are composed of granulation tissue and a significant quantity of cholesterol crystals. The etiology of the disease is primarily associated with microtraumas in the affected structures, which result in the rupture of small blood vessels. This phenomenon leads to the accumulation of formed elements and cholesterol in the affected regions, resulting in the formation of a foreign-body-type granuloma that gradually increases in size. The process is both expansive and destructive, characterized by gradual and painless development.

PMID:
42677707
Bibliographic data and abstract were imported from PubMed on 01 Sep 2026.

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