Adverse pregnancy outcomes and long-term cardiovascular risk: lifelong connections.

Authors

Veronica Giorgione, Nisha I Parikh, Daniela Pedicino, Basky Thilaganathan

Published in

European heart journal. Sep 01, 2026. Epub Sep 01, 2026.

Abstract

Pregnancy represents a critical period during which the maternal cardiovascular system adapts to profound haemodynamic and metabolic demands. When these adaptive mechanisms are impaired, adverse pregnancy outcomes (APOs)-including hypertensive disorders of pregnancy, gestational diabetes, pre-term birth, small-for-gestational-age birth, and pregnancy loss-occur. Extensive epidemiological evidence demonstrates that APOs are not isolated obstetric events but early clinical markers of cardiometabolic dysfunction that identify women at increased risk of coronary artery disease, heart failure, stroke, chronic kidney disease, and premature cardiovascular mortality. Shared mechanisms include endothelial dysfunction, inflammation, and insulin resistance, establishing a continuum between obstetric complications and later cardiovascular disease. Early post-partum studies reveal persistent hypertension, adverse cardiac remodelling, and metabolic abnormalities that mediate much of the long-term excess cardiovascular risk. These findings redefine the 'fourth trimester' as a preventive window in which timely blood pressure surveillance, metabolic screening, and lifestyle optimization can yield durable cardiovascular benefit. Integrated cardio-obstetric care models, digital follow-up, and systematic transition to primary care are crucial for maintaining long-term prevention. Addressing persistent gaps in limited provider awareness, fragmented follow-up, and disparities across socially disadvantaged populations remains critical. Recognizing pregnancy complications as indicators of underlying cardiovascular vulnerability offers an opportunity to shift prevention upstream and promote lifelong cardiovascular health for women.

PMID:
42678068
Bibliographic data and abstract were imported from PubMed on 01 Sep 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.