Intramolecular hydrogen bonding topology modulates fluorescence in C4N4 fluorophores.

Authors

Miki Kohei, Mao Niimura, Ryosuke Tsutsumi, Naoya Kumagai

Published in

Organic & biomolecular chemistry. Sep 01, 2026. Epub Sep 01, 2026.

Abstract

Systematic comparison of hydroxy-, amino-, amide-, sulfonamide-, and phosphinamide-substituted C4N4 fluorophores revealed that fluorescence is modulated not simply by hydrogen-bond donor strength, but by positional, geometrical, and conformational accessibility of intramolecular hydrogen bonding to the pyrimidine core. This insight was translated into an acetylation-responsive turn-on probe, providing a design basis for responsive C4N4 fluorophores.

PMID:
42678290
Bibliographic data and abstract were imported from PubMed on 01 Sep 2026.

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