Electrophoretic Deposition and Characterization of Multicomponent Chitosan/Eudragit or Poly(4-vinylpyridine) Coatings Incorporating Mesoporous Bioactive Glass and Silver Nanoparticles on Ti-13Nb-13Zr Alloy.

Authors

Łukasz Pawłowski, Yi-Xin Liu, Chen-Ying Su, Aleksandra Mirowska, Muhammad Asim Akhtar, Magdalena Narajczyk, Joanna Sypniewska, Agata Knabe, Anna Ronowska, Adrianna Banach-Kopeć, Oskar Ronda, Aleksandra Mielewczyk-Gryń, Aldo Roberto Boccaccini, Hsu-Wei Fang

Published in

ACS biomaterials science & engineering. Aug 27, 2026. Epub Aug 27, 2026.

Abstract

In this study, multifunctional composite coatings based on chitosan (CS), mesoporous bioactive glass nanoparticles (MBGNPs), and silver nanoparticles (AgNPs) were successfully deposited on Ti-13Nb-13Zr alloy by electrophoretic deposition (EPD). Two coating systems containing Eudragit E100 (EE100) or poly(4-vinylpyridine) (P4VP) were developed to tailor physicochemical and biological properties. The synthesized MBGNPs exhibited a spherical morphology with an average particle size of approximately 80 nm, as observed by TEM, while XRD analysis confirmed their amorphous structure. Both coatings formed uniform porous layers (∼10 µm thick) with excellent adhesion to the substrate (class 1, EN ISO 2409). Surface characterization revealed significantly increased roughness and distinct wettability behavior depending on polymer composition. CS/EE100 coatings exhibited hydrophobic character and low surface free energy, whereas CS/P4VP coatings showed highly hydrophilic behavior with increased surface energy. Electrochemical studies demonstrated enhanced electrochemical activity of coated samples, particularly for the P4VP-based system, associated with its porous and hydrophilic structure. Ion release studies confirmed time-dependent calcium release from MBGNPs and significantly higher silver ion release from CS/P4VP coatings, especially under acidic conditions. Both coatings exhibited strong antibacterial activity against Escherichia coli and Staphylococcus aureus, achieving up to ∼2.4 log reduction. Cytocompatibility studies using hFOB 1.19 osteoblast-like cells demonstrated that the CS/P4VP/MBGNPs/AgNPs coating maintained high cell viability (>80%) despite increased Ag+ release, while both coatings maintained alkaline phosphatase activity. Overall, the P4VP-based coating demonstrated the most favorable balance between antibacterial activity, ion release, and cytocompatibility, highlighting its potential for advanced biomedical implant applications.

PMID:
42679020
Bibliographic data and abstract were imported from PubMed on 02 Sep 2026.

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