Authors
Andrea Vilaplana, Asbleidy Carolina Torres, Adela Escudero López, Elisa Izquierdo, Sergio Manresa-Vera, Josep Escrivá-Fernández, Piedad Alba-Pavón, Lide Alaña, Angela Gutierrez-Camino, Carlos Rodríguez-Antolín, Clara Venegas Mascaró, Sonia Paco Mercader, Noelia Salvador, Ana Chamorro-Vera, Teresa Imízcoz, Elena Panizo Morgado, Beatriz Vergara-Muñoz, Antonio Juan-Ribelles, Nuria Benavent, Alicia Castañeda Heredia, Carlota Rovira Zurriaga, Lorena Valero-Arrese, Raquel Díaz-Merchán, Irene Manzano-Benito, Saint T Cervera, Laura García-Calvo, Irene Jiménez, Nerea Domínguez-Pinilla, Cristina Nova-Lozano, Isabel Cuadrado-Torroglosa, Jesús Sánchez-Ruiz, Tamara Mondejar, Antonio Pérez-Martínez, Ana Fernández-Teijeiro, Palma Solano-Páez, Josep Roma, Jaime Font de Mora, Bárbara Meléndez, Alba Rubio-San-Simón, Cristina Saiz-Ladera, Itziar Astigarraga, Adela Cañete, Javier Alonso, Cinzia Lavarino, Ana Patiño-García, Lucas Moreno, Aroa Soriano, SEHOP-PENCIL Consortium
Published in
JCO precision oncology. Volume 10. Issue 9. Pages e2600074. Epub Sep 01, 2026.
Abstract
Pediatric cancer care in Spain lacked a national personalized medicine program. The SEHOP-PENCIL initiative, established by the SEHOP, was designed to address this gap. A national survey identified the genomic sequencing needs of hospitals treating pediatric patients with cancer. Results showed improved access to targeted next-generation sequencing panels but revealed persistent variability in implementation, limited availability of advanced sequencing (whole-exome sequencing, whole-genome sequencing, RNA sequencing, and DNA methylation profiling), and gaps in cancer predisposition clinics and molecular tumor boards (MTBs). SEHOP-PENCIL is organized as a network of 10 specialized genomic centers serving 45 hospitals through a centralized inclusion system. The program standardizes patient eligibility, genomic workflows, and result interpretation, supported by a national MTB. This framework enables informed clinical decision making, ensures access to molecular diagnosis and innovative therapies, and supports systematic data collection to advance pediatric cancer research and personalized care. SEHOP-PENCIL represents a pioneering national model for integrating precision oncology into pediatric cancer care in Spain. By fostering collaboration, standardizing genomic practices, and promoting equitable access, it aims to reduce disparities and improve outcomes, offering a scalable example for other decentralized health care systems.
PMID:
42679328
Bibliographic data and abstract were imported from PubMed on 02 Sep 2026.
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