Effect of trilostane treatment on proteinuria secondary to spontaneous hypercortisolism in dogs.

Authors

Filippo Tagliasacchi, Federico Fracassi, Maddalena Poli, Laura Dalla Tomba, Stefania Golinelli, Antonio Maria Tardo, Francesca Del Baldo

Published in

Journal of veterinary internal medicine. Volume 40. Issue 5. Sep 01, 2026.

Abstract

Proteinuria is reported in 68%-71% of dogs with spontaneous hypercortisolism (HC). The long-term effect of trilostane on HC-associated proteinuria remains poorly documented.
To evaluate the efficacy of trilostane on proteinuria in dogs with HC and identify potential clinical, anamnestic, and analytical differences between responders and nonresponders.
Retrospective longitudinal cohort study including dogs with proteinuric HC treated exclusively with trilostane. Clinical history and laboratory data at diagnosis (T0) were retrieved. When available, urine protein-to-creatinine ratio (UPC), disease clinical score (DCS), blood pressure (BP), and daily trilostane dosage (TD) were recorded at 30, 90, 180, and 365 days (T30, T90, T180, and T365) after treatment initiation. Dogs achieving a ≥ 50% UPC reduction or a final UPC < 0.5 were defined as "responders."
One hundred sixty dogs met inclusion criteria: 89% had pituitary-dependent HC and 10% adrenal-dependent HC. At diagnosis, 64% were proteinuric. A significant UPC reduction over time occurred (P = .0005; F(4,153.9) = 5.26), with statistically significant decreases at T90 (P = .020; difference, 1.093; 95% CI, 0.115-2.071), T180 (P = .031; difference, 1.122; 95% CI, 0.064-2.181), and T365 (P = .002; difference, 1.599; 95% CI, 0.436-2.761) compared to baseline. At the last follow-up, 76 dogs were evaluable; 48% were responders and had lower median DCS, BP, and TD (P = .029, P = .025, and P = .048, respectively) than nonresponders.
Trilostane induces a significant and sustained reduction in proteinuria in some dogs with spontaneous HC, evident from 3 months of treatment. Responders exhibit better control of hypertension and clinical signs despite lower TD. Nonresponders account for 52% of proteinuric dogs.

PMID:
42679217
Bibliographic data and abstract were imported from PubMed on 02 Sep 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.