Authors
Jin Zhang, Yandai Lin, Zhe Lin, Qi Wei, Jiaqi Qian, Renjie Ruan, Xiancai Jiang, Linxi Hou, Jibin Song, Jianxun Ding, Huanghao Yang
Published in
Advanced science (Weinheim, Baden-Wurttemberg, Germany). Volume 9. Issue 5. Pages e2103444. Epub Dec 19, 2021.
Abstract
Cancer immunotherapy has achieved promising clinical progress over the recent years for its potential to treat metastatic tumors and inhibit their recurrences effectively. However, low patient response rates and dose-limiting toxicity remain as major dilemmas for immunotherapy. Stimuli-responsive nanoparticles (srNPs) combined with immunotherapy offer the possibility to amplify anti-tumor immune responses, where the weak acidity, high concentration of glutathione, overexpressions of enzymes, and reactive oxygen species, and external stimuli in tumors act as triggers for controlled drug release. This review highlights the design of srNPs based on tumor microenvironment and/or external stimuli to combine with different anti-tumor drugs, especially the immunoregulatory agents, which eventually realize synergistic immunotherapy of malignant primary or metastatic tumors and acquire a long-term immune memory to prevent tumor recurrence. The authors hope that this review can provide theoretical guidance for the construction and clinical transformation of smart srNPs for controlled drug delivery in synergistic cancer immunotherapy.
PMID:
34927373
Bibliographic data and abstract were imported from PubMed on 02 Sep 2026.
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