CAR transgenic T-cell lymphoproliferative neoplasm (CTTLN): malignant transformation of cellular immunotherapy.

Authors

Francis Baumgartner, Michael J Dickinson, Piers Blombery

Published in

Blood. Sep 01, 2026. Epub Sep 01, 2026.

Abstract

Engineered T-cells have transformed hematooncology, but CAR transgene-bearing T-cell malignancies have emerged as a rare and serious genomic safety signal after CAR-T therapy. Available data support a multistep model in which pre-existing clonal fitness, CAR-T manufacture, vector integration, construct biology and post-infusion selection may contribute to different degrees. We review reported cases of CAR-transgenic T-cell lymphoproliferative neoplasms (CTTLN) and propose practical diagnostic criteria with a proportionate approach to genomic surveillance.

PMID:
42683850
Bibliographic data and abstract were imported from PubMed on 02 Sep 2026.

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